Thursday 6th

9.00-9.10 Welcome

9.10-9.40

Stefano Gianni (Roma), Understanding the binding induced folding reaction of intrinsically disordered proteins.

9.50-10.20

Andrea Pagnani (polito), Exploiting co-evolution across protein families for predicting  protein-protein interactions surfaces.

10.30-11.00

Tatjana Skrbic (Padova/SISSA), Predicting the binding affinities of protein complexes:

the role of entropic contributions

coffee break

11.30-12.00

Annalisa Relini (Genova), Effect of interfaces on the aggregation of the β2-microglobulin D76N variant

12.10-12.40

Alessandro Barducci (Lausanne), Hp70 chaperones as non-equilibrium machines: hyperaffinity from energy consumption.

lunch break

14.00-14.30

Mauro Manno (CNR Palermo), Electrostatic repulsion mimics molecular crowding and selects the fibrillation pathway in fibril-forming protein solutions.

14.40-15.10

Giovanna Musco (Telethon, Milano), The double life of PHD fingers: epigenetic readers or structural hubs for multiple interactions?

15.20-15.50

Pietro Faccioli (Trento), Non-equilibrium internal equilibrium dynamics in biomolecules: from conformational changes to quantum transport

coffee break

16.30-17.00

Carlo Camilloni (Cambridge), A “low resolution” characterisation of the unfolded state of ACBP.

17.10-17.40

Federico Fogolari (Udine), Generalized Born forces for biomolecular simulations.

17.50-18.40

short talks:

            Sandro Bottaro (SISSA) RNA 3D Structure in a Nutshell

            Daniela Bonetti (Roma), A single amino-acid substitution induces a protein to switch from a alpha/beta

                                                    to an all-alpha fold

            Angelo Toto (Roma), The folding pathway of frataxin

            Stefano Zamuner (Padova), Constrained conformational changes of polymers

Friday 7th

9.00-9.30

Sonia Longhi (Marseille), Structural disorder and induced folding in the nucleoproteins and phosphoproteins of paramyxoviruses

9.40-10.10

Fabrizio Chiti (Firenze), The structural determinants of protein oligomer toxicity

10.20-10.50

Pierandrea Temussi (Napoli), Cold denaturation as a tool to assess protein stability.

coffee break

11.30-12.00

Alex Rodriguez (SISSA), Clustering by fast search-and-find of density peaks

12.10-12.40

Gian Gaetano Tartaglia (CRG, Barcelona), Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein.

lunch break

14.00-14.30

Annalisa Pastore (MRC, London), Protein-protein interactions as a strategy towards protein-specific drug design

14.40-15.10

Gianluca Lattanzi (Bari), Human Aquaporin 4: theory meets experiments and faces new challenges.

15.20-15.50

Marco Zamparo (polito), Nonequilibrium dynamics of an exactly solvable Ising-like model

and protein translocation.

coffee break

16.20-16.50

Stefano Piana (D.E. Shaw Co.), Assessing the accuracy of physical models used in protein-folding simulations: lessons learned and open questions.

17.00-17.30

Stefano Ricagno (Milano), D76N Beta-2 microglobulin, an amyloidogenic and pathologic mutant (clues on the native and on the fibrillar states)

17.40-18.10

Silvio C. E. Tosatto (Padova),  The many faces of intrinsic protein disorder

  

Saturday 8th

9.00-9.30

Giuseppe Zanotti (Padova), Solving the phase problem in macromolecular crystallography by ab-initio molecular models?

9.40-10.10

Giovanni Bussi (SISSA), RNAs in silico: learning from molecular dynamics and enhanced sampling techniques.

10.20-10.50

Francesco Spinozzi (Ancona), Quaternary structure of protein assemblies from small-angle x-ray and neutron scattering

coffee break

11.30-12.00

Cristian Micheletti (SISSA), Colocalization of Coregulated Genes: A Steered Molecular Dynamics Study of Human Chromosome 19

12.10-12.40

short talks:

            Elia Schneider (Trento), Quantum biology: a theoretical study of quantum transport in biomolecules.

            Matteo de Rosa (Milano), Structural basis for Z-DNA binding and stabilization by the zebrafish Z-DNA

                                                      dependent protein kinase (PKZ)

            Oliver Carrillo (Padova), A theoretical approach for describing the Misfolding Process of Amyloid Proteins

            Carmen Maria Livi (Barcelona), Protein-specific prediction of messenger RNA binding using Support

                                                              Vector Machines