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Presented at |
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Specialization School on Health Physics |
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Universita’ degli Studi di Milano |
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By Dennis R. Phillips |
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Radioisotope Applications and Production |
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Isotope and Nuclear Chemistry Group |
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March 21, 2002 |
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Sr-82 (t1/2 = 25.4 d)/Rb-82 (t1/2
= 1.26 m) |
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Rubidium-82 used for PET myocardial
perfusion imaging |
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Distributed by Bracco Diagnostics |
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Manufactured first by Bristol Myers Squibb until
May 2001; Now by Amersham Medical |
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Dissolve target in 30% H2O2 |
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Pass solution through cation exchange column |
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Wash with 10% H2O2 |
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Elute column 6 M HCl |
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Convert to 0.1 M HCl |
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Load onto new cation column |
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Wash column with 0.5 M H2SO4 |
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Elute Sr-82 with 1 M HCl |
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CU 112C Specifications |
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DOT/IAEA Type A |
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30 gal SS Drum Outer Assembly (17 kg) |
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SS/Lead Pot Inner Container (328 kg) |
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Inner Cavity |
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7.19 cm Diameter |
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16.5 cm Height |
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50 g Rb |
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94 - 101 MeV Incident Protons, up to 130 mA beam
current |
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6800 microampere hours (2 – 3 days irradiation
time, ~30 days before delivery date) |
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1500 mCi Sr-82 at delivery date |
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Dissolve target in 2-propanol in Argon inerted
atmosphere |
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Convert rubidium propoxide to RbCl |
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Dissolve RbCl in 6 M HCl |
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Pass through anion column to remove iron |
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Evaporate eluate to dryness |
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Dissolve RbCl in 0.1 M NH3/NH4+
buffer solution (pH 9 - 10); filter to remove Al |
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Pass filtrate through Chelex 100 ion exchange
column; Sr retained, Rb in eluate |
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Wash column with buffer, then water |
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Elute Sr-82 with 4 M HCl |
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Evaporate to dryness |
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Dissolve in 0.1 M HCl |
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Pass through cation column (Sr retained, trace
rubidium and “color” in eluate) |
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Wash gradiently with 0.1, 0.5, and 1.0 M HCl |
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Elute Sr-82 from column with 4 M HCl |
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Evaporate eluate to dryness |
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Add Concentrated HNO3 to residue and
evaporate to dryness |
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Convert back to chloride, 0.1 M HCl product
solution |
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8 - 9 g RbCl |
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66 - 40 MeV protons |
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80 microampere beam current |
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5000 microampere-hours |
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500 - 700 mCi
Sr-82 EOB |
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Dissolve target in water, Evaporate to dryness |
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Dissolve residue in 0.1 M NH3/NH4+
buffer solution (pH 9 -10) |
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Wash column with buffer, then water |
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Elute Sr-82 with 6 M HCl |
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Evaporate to dryness |
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Dissolve in 0.1 M HCl |
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Pass through cation column (Sr retained) |
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Wash gradiently with 0.1, 0.5, and 1.0 M HCl |
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Elute Sr-82 from column with 4 M HCl |
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Evaporate eluate to dryness |
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Add Concentrated HNO3 to residue and
evaporate to dryness |
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Convert back to chloride, 0.1 M HCl product
solution |
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Place gallium target (~4 g) and niobium
encapsulation (~5 g) in ~ 60 mL Conc. HF |
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Slowly add ~ 10 mL Conc. HNO3 to
dissolve |
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Add ~15 mL Conc. H2SO4 ;
reduce volume by evaporation to ~15 mL to remove HF |
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Add ~120 mL Conc. HCl |
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Extract Ge into CCl4 |
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Back extract Ge into H2O |
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Pass the germanium depleted aqueous target
solution through 5 - 15 g alumina column (equilibrated with 12 M HCl) |
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Zr-88/Y-88 retained on column |
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Rinse column 2x with 12 M HCl to remove gallium
and niobium mass |
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Elute Zr-88 from column with solution of
1M HF/1M HCL; Y-88 retained |
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Note
